Bone fracture risk in Postmenopausal HIV-infected Women

Assam News · January 5, 2010

HIV-infected postmenopausal women are at high risk for bone loss and fractures, the findings of a new study suggests. According to the study, to be published in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM), low bone mineral density and high bone turnover increases the risk for future bone fractures in postmenopausal HIV-infected women.

HIV-infected "As HIV-infected individuals live longer with potent antiretroviral therapy (ART), metabolic complications such as low bone density and osteoporosis are increasingly recognized," said Michael Yin, MD of Columbia University Medical Center in New York and lead author of the study. To test their hypothesis, Yin and his colleagues initiated a longitudinal study to assess bone health in 92 HIV-positive and 95 HIV-negative postmenopausal women. Bone mineral density of the lumbar spine, femoral neck and hip as well as body composition were measured by dual x-ray absorptiometry (DXA). Researchers found that HIV-positive postmenopausal women had lower bone mineral density at both the spine and hip than HIV-negative postmenopausal women.

"HIV infection was independently associated with lower bone mineral density after adjusting for body mass index (BMI) and traditional osteoporosis risk factors," said Yin. "While the reason for HIV-associated bone loss remains unclear, it may be related to increased levels of cytokines (proteins produced by cells that aid communication between cells), direct effects of antiretrovirals on bone cells or hormonal/nutritional deficiencies that are common in HIV."

"Estrogen protects against the effect of cytokines on bone resorption," said Yin. "Therefore, as HIV-positive women become estrogen deficient during menopause, they may be at higher risk for accelerated bone loss and fracture", Yin concluded.

Source: The Endocrine Society

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